A second independence referendum has become "even more likely" following the Prime Minister's speech, the First Minister has said.

In an interview with STV News, Nicola Sturgeon also criticised Downing Street's handling of Brexit, saying only the Scottish Government is prepared to compromise over its wishes.

The Scottish Government warned Theresa May a second independence referendum may take place if Scotland is removed from the European single market.

In a speech in London on Tuesday, the Prime Minister outlined that she intends to take the UK out of the single market despite Sturgeon's warning.

Downing Street confirmed to STV News that the Prime Minister and the First Minister had talked on the phone before the speech.

When questioned on how this changes the likelihood of a referendum, Sturgeon replied: "Well, I've already said it is highly likely. The Prime Minister today, I think, has made it even more likely.

"I have done my best, and will continue to do my best, to compromise. But for a compromise to work you have to have two willing partners willing to compromise.

"So far it is the only Scottish Government that has been prepared to compromise. I said the morning after the referendum that we would examine all options - I would exhaust all options - and that is what I have done."

The First Minister continued: "If it comes down to Scotland being taken down a path that fundamentally changes the very nature of our country then I don't think that should be allowed to happen without the people of Scotland getting the opportunity to decide if that is what they want or do they want to choose something better.

"To take control of our own future into our own hands so that we can have a future where there is a genuine partnership of equals within the UK so we can also play our part in the world and protects our values which we hold so dear."

Sturgeon said she will take decisions over a second referendum in a "orderly and responsible fashion" and if it is the only way to "protect" Scotland's interests "it will happen".

The SNP leader has already ruled out holding one this year but has previously said one would be held within the Brexit negotiation period.

During her speech the Prime Minister said she would put protecting the union between Scotland the rest of the United Kingdom "at the heart" of her government's Brexit negotiations.

May described the union as "precious" and only through unity can the UK "make the most of opportunities ahead".