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Science behind smell of Parkinson’s discovered by researchers

A woman’s ability to smell the disease has led scientists to identify what causes the odour.

Scientists: An early diagnosis tool could be developed.
Scientists: An early diagnosis tool could be developed. Pixabay

A Scottish woman's ability to smell Parkinson's disease has led scientists to identify what causes the telltale odour, raising hopes for a new early diagnosis tool.

Joy Milne, a retired nurse from Perth, said she detected a subtle change in how her late husband Les smelled prior to him being diagnosed with the progressive neurological condition.

Super-smell: Joy Milne with late husband Les.
Super-smell: Joy Milne with late husband Les. Parkinson's UK

The 68-year-old described it as a "musky" scent and approached a researcher at a Parkinson's UK lecture.

A Manchester University study inspired by her apparent ability to smell a substance associated with the condition began in 2015 and the findings are now being published in the journal ACS Central Science.

There are hopes the discovery could help diagnose people with the condition earlier and before problems with motor control emerge.

'What we found are some compounds that are more present in people who have got Parkinson's disease and the reason we've discovered them is because Joy Milne could smell a difference'
Professor Perdita Barran

Professor Perdita Barran, a lead author of the study, said: "What we found are some compounds that are more present in people who have got Parkinson's disease and the reason we've discovered them is because Joy Milne could smell a difference.

"She could smell people who've got Parkinson's disease."

The scientists designed experiments to mimic Mrs Milne's sense of smell by using a piece of equipment called a mass spectrometer.

The "volatile biomarkers" they identified could help to develop a simple test for early detection of the disease.

Professor Barran said: "What we might hope is if we can diagnose people earlier, before the motor symptoms come in, that there will be treatments that can prevent the disease spreading. So that's really the ultimate ambition."

Around one adult in every 350 in the UK have Parkinson's, which can leave people struggling to walk, speak and sleep.

Some 145,000 people in the UK live with the condition.

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